This study aimed to evaluate and compare, using the methodology of Franz diffusion cells,\nthe ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional suspension.\nThe second aim was to show that this methodology might be easily applied for the development\nof semi-solid prototypes and claim proof in pre-formulation stages. Drug release analysis was\ncarried out under physiological conditions (pH: 5.6 to 7.4; ionic strength 0.15 M; at .... for\n24 h. Three independent vertical Franz cells were used with a nominal volume of the acceptor\ncompartment of 125 mL and a diffusion area of 2.5 cm2. Additionally, two different membranes\nwere evaluated: A generic type (regenerated cellulose) and a transdermal simulation type (Strat-M®).\nThe KTP permeation profiles demonstrated that depending on the membrane type and the vehicle\nused, the permeation is strongly affected. High permeation efficiencies were obtained for the\ngel formulation, and the opposite effect was observed for the suspension formulation. Moreover,\nthe permeation studies using Strat-M membranes represent a reproducible methodology, which is\neasy to implement for pre-formulation stage or performance evaluation of semi-solid pharmaceutical\nproducts for topical or transdermal administration.
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